-
Santomauro, D. F. et al. Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. , 1700–1712 (2021).
pubmed_reference_list
-
American Psychiatric Association. (The American Psychiatric Association Publishing, 2013).
pubmed_reference_list
-
Hofmann, S. G., Asnaani, A., Vonk, I. J. J., Sawyer, A. T. & Fang, A. The efficacy of cognitive behavioral therapy: a review of meta-analyses. , 427–440 (2012).
pubmed_reference_list
-
Carona, C. The philosophical assumptions across the ‘three waves’ of cognitive–behavioural therapy: how compatible are they? , 213–217 (2023).
pubmed_reference_list
-
Powers, M. B., de Kleine, R. A. & Smits, J. A. J. Core mechanisms of cognitive behavioral therapy for anxiety and depression: a review. , 611–623 (2017).
pubmed_reference_list
-
Patel, V. et al. Treatment and prevention of mental disorders in low-income and middle-income countries. , 991–1005 (2007).
pubmed_reference_list
-
Patel, V., Chowdhary, N., Rahman, A. & Verdeli, H. Improving access to psychological treatments: Lessons from developing countries. , 523–528 (2011).
pubmed_reference_list
-
Haenlein, M. & Kaplan, A. A brief history of artificial intelligence: on the past, present, and future of artificial intelligence. , 5–14 (2019).
pubmed_reference_list
-
Adamopoulou, E. & Moussiades, L. An overview of chatbot technology. , 373–383 (2020).
pubmed_reference_list
-
Hua, Y. et al. Charting the evolution of artificial intelligence mental health chatbots from rule-based systems to large language models: a systematic review. , 383–394 (2025).
pubmed_reference_list
-
Zhang, Z. Advancements and challenges in AI-driven language technologies: from natural language processing to language acquisition. , 146–152 (2024).
pubmed_reference_list
-
Oh, J., Jang, S., Kim, H. & Kim, J. Efficacy of mobile app-based interactive cognitive behavioral therapy using a chatbot for panic disorder. , 104171 (2020).
pubmed_reference_list
-
Jang, S. et al. Mobile app-based chatbot to deliver cognitive behavioral therapy and psychoeducation for adults with attention deficit: a development and feasibility/usability study. , 104440 (2021).
pubmed_reference_list
-
Egan, S. et al. A pilot study of the perceptions and acceptability of guidance using artificial intelligence in internet cognitive behaviour therapy for perfectionism in young people. , 100711 (2024).
pubmed_reference_list
-
Keinert, M. et al. Facing depression: evaluating the efficacy of the EmpkinS-EKSpression reappraisal training augmented with facial expressions—protocol of a randomized controlled trial. , 896 (2024).
pubmed_reference_list
-
Lim, S., Shiau, C., Cheng, L. & Lau, Y. Chatbot-delivered psychotherapy for adults with depressive and anxiety symptoms: a systematic review and meta-regression. , 334–347 (2022).
pubmed_reference_list
-
Li, H., Zhang, R., Lee, Y.-C., Kraut, R. E. & Mohr, D. C. Systematic review and meta-analysis of AI-based conversational agents for promoting mental health and well-being. , 1–14 (2023).
pubmed_reference_list
-
Hunt, M., Miguez, S., Dukas, B., Onwude, O. & White, S. Efficacy of Zemedy, a mobile digital therapeutic for the self-management of irritable bowel syndrome: crossover randomized controlled trial. , e26152 (2021).
pubmed_reference_list
-
Prochaska, J. et al. A therapeutic relational agent for reducing problematic substance use (Woebot): development and usability study. , e24850 (2021).
pubmed_reference_list
-
Cheng, A. et al. Behavioral mechanisms that mediate mental and physical health improvements in people with chronic pain who receive a digital health intervention: prospective cohort pilot study. , e51422 (2023).
pubmed_reference_list
-
Chan, W. et al. Assessing the short-term efficacy of digital cognitive behavioral therapy for insomnia with different types of coaching: randomized controlled comparative trial. , e51716 (2024).
pubmed_reference_list
-
Herbener, A., Klincewicz, M. & Damholdt, M. A narrative review of the active ingredients in psychotherapy delivered by conversational agents. . , 100401 (2024).
pubmed_reference_list
-
Karkosz, S., Szymanski, R., Sanna, K. & Michalowski, J. Effectiveness of a web-based and mobile therapy chatbot on anxiety and depressive symptoms in subclinical young adults: randomized controlled trial. , e47960 (2024).
pubmed_reference_list
-
Fulmer, R., Joerin, A., Gentile, B., Lakerink, L. & Rauws, M. Using psychological artificial intelligence (tess) to relieve symptoms of depression and anxiety: randomized controlled trial. , e64 (2018).
pubmed_reference_list
-
Bennion, M., Hardy, G., Moore, R., Kellett, S. & Millings, A. Usability, acceptability, and effectiveness of web-based conversational agents to facilitate problem solving in older adults: controlled study. , e16794 (2020).
pubmed_reference_list
-
Bird, T., Mansell, W., Wright, J., Gaffney, H. & Tai, S. Manage your life online: a web-based randomized controlled trial evaluating the effectiveness of a problem-solving intervention in a student sample. , 570–582 (2018).
pubmed_reference_list
-
Danieli, M. et al. Assessing the impact of conversational artificial intelligence in the treatment of stress and anxiety in aging adults: randomized controlled trial. , e38067 (2022).
pubmed_reference_list
-
Fitzsimmons-Craft, E. et al. Effectiveness of a chatbot for eating disorders prevention: a randomized clinical trial. , 343–353 (2022).
pubmed_reference_list
-
He, Y. et al. Mental health chatbot for young adults with depressive symptoms during the COVID-19 pandemic: single-blind, three-arm randomized controlled trial. , e40719 (2022).
pubmed_reference_list
-
Jonassaint, C. R. et al. Digital cognitive behavioral therapy vs education for pain in adults with sickle cell disease. , 6257–6266 (2024).
pubmed_reference_list
-
Keinonen, K. et al. Brief online ACT intervention to improve adolescents’ well-being: Effectiveness among adolescents with depressive symptoms during COVID-19. , 107671 (2024).
pubmed_reference_list
-
Lappalainen, P. et al. In the shadow of COVID-19: a randomized controlled online ACT trial promoting adolescent psychological flexibility and self-compassion. , 34–44 (2023).
pubmed_reference_list
-
Liu, H., Peng, H., Song, X., Xu, C. & Zhang, M. Using AI chatbots to provide self-help depression interventions for university students: a randomized trial of effectiveness. , 100495 (2022).
pubmed_reference_list
-
Lorenz, N., Heim, E., Roetger, A., Birrer, E. & Maercker, A. Randomized controlled trial to test the efficacy of an unguided online intervention with automated feedback for the treatment of insomnia. , 287–302 (2019).
pubmed_reference_list
-
Sabour, S. et al. A chatbot for mental health support: exploring the impact of Emohaa on reducing mental distress in China. , 1133987 (2023).
pubmed_reference_list
-
Six, S., Schlesener, E., Hill, V., Babu, S. V. & Byrne, K. Impact of conversational and animation features of a mental health app virtual agent on depressive symptoms and user experience among college students: randomized controlled trial. , e67381 (2025).
pubmed_reference_list
-
Andrade, C. Intent-to-treat (ITT) vs completer or per-protocol analysis in randomized controlled trials. , 416–418 (2022).
pubmed_reference_list
-
Papola, D. et al. Psychotherapies for generalized anxiety disorder in adults. , 250–259 (2024).
pubmed_reference_list
-
Hancock, K. M. et al. Acceptance and commitment therapy versus cognitive behavior therapy for children with anxiety: outcomes of a randomized controlled trial. , 296–311 (2018).
pubmed_reference_list
-
Marasigan, P. R. Using brief cognitive restructuring and cognitive defusion techniques to cope with negative thoughts. , 11–14 (2019).
pubmed_reference_list
-
Xu, H., Wang, Y., Xun, Y., Shao, R. & Jiao, Y. Artificial intelligence for clinical reasoning: the reliability challenge and path to evidence-based practice. , 802–804 (2025).
pubmed_reference_list
-
Kim, M., Yang, J., Ahn, W. & Choi, H. Machine learning analysis to identify digital behavioral phenotypes for engagement and health outcome efficacy of an mHealth intervention for obesity: randomized controlled trial. , e27218 (2021).
pubmed_reference_list
-
Rajeshkumar, L. et al. Computer-assisted cognitive behavior therapy and mobile apps for depression and anxiety: evidence-based digital tools for clinical practice. , 389–399 (2024).
pubmed_reference_list
-
Tabares, M., Landa, E., Alvarez, C., Gallego, P. & Salcedo, J. Can chatbots alleviate depression? results of a systematic review. , 2665–2686 (2024).
pubmed_reference_list
-
Loveys, K., Hiko, C., Sagar, M., Zhang, X. & Broadbent, E. “I felt her company”: a qualitative study on factors affecting closeness and emotional support seeking with an embodied conversational agent. , 102771 (2022).
pubmed_reference_list
-
Striegl, J., Gotthardt, M., Loitsch, C. & Weber, G. Investigating the Usability of Voice Assistant-Based CBT for Age-Related Depression. In (eds Miesenberger, K. et al.) 432–441 (Springer International Publishing, 2022).
pubmed_reference_list
-
Wang, L. et al. Evaluating generative AI in mental health: systematic review of capabilities and limitations. , e70014 (2025).
pubmed_reference_list
-
Burns, P. B., Rohrich, R. J. & Chung, K. C. The levels of evidence and their role in evidence-based medicine. , 305–310 (2011).
pubmed_reference_list
-
Bruijniks, S. et al. The relation between therapy quality, therapy processes and outcomes and identifying for whom therapy quality matters in CBT and IPT for depression. , 103815 (2021).
pubmed_reference_list
-
Page, M. J. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. , n71 (2021).
pubmed_reference_list
-
Villarreal-Zegarra, D. et al. Self-administered interventions based on natural language processing models for reducing depressive and anxiety symptoms: systematic review and meta-analysis. , e59560 (2024).
pubmed_reference_list
-
Vaswani, A. et al. Attention is all you need. In 6000–6010 (Curran Associates Inc., Red Hook, NY, USA, 2017).
pubmed_reference_list
-
Landis, J. R. & Koch, G. G. The measurement of observer agreement for categorical data. , 159–174 (1977).
pubmed_reference_list
-
Sterne, J. A. et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. , l4898 (2019).
pubmed_reference_list