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    "doi": "10.1159\/000548961",
    "status": "found",
    "title": "Clinical and Neuroimaging Effects of Mindfulness-Based Cognitive Therapy for Symptomatic Obsessive-Compulsive Disorder Patients after First-Line Treatments: A Randomised Controlled Trial",
    "authors": [
        "Maria Serra-Blasco",
        "Neus Miquel-Giner",
        "Muriel Vicent-Gil",
        "Daniel Porta-Casteràs",
        "Ignacio Martínez-Zalacaín",
        "Marta Cano",
        "Víctor De la Peña-Arteaga",
        "Lorea Mar-Barrutia",
        "Maria Alemany-Navarro",
        "Carles Soriano-Mas",
        "Marina López-Solà",
        "Jessica R. Andrews-Hanna",
        "Maria J. Portella",
        "Joaquim Soler",
        "Narcís Cardoner",
        "Pino Alonso",
        "Clara López-Solà"
    ],
    "container": "Psychotherapy and Psychosomatics",
    "year": "2025",
    "doi_url": "https:\/\/doi.org\/10.1159\/000548961",
    "is_open_access": true,
    "oa_status": "hybrid",
    "best_landing_page": "https:\/\/pubmed.ncbi.nlm.nih.gov\/41115123",
    "best_pdf": "https:\/\/karger.com\/pps\/article-pdf\/doi\/10.1159\/000548961\/4455418\/000548961.pdf",
    "abstract": "Introduction: Obsessive-compulsive disorder (OCD) is a chronic condition where many patients remain symptomatic despite first-line treatments such as cognitive behavioural therapy and selective serotonin reuptake inhibitors. This randomised controlled trial evaluated mindfulness-based cognitive therapy (MBCT) efficacy as an augmentation strategy and its impact on brain functional connectivity. METHODS: Sixty-eight participants with moderately symptomatic OCD were randomised into MBCT or treatment as usual (TAU). Clinical outcomes were evaluated using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and the Obsessive-Compulsive Inventory, alongside other relevant secondary outcomes. Data were analysed using repeated-measures ANOVA to assess time * group effects. Neuroimaging functional measures (resting-state network connectivity) were collected before and after the intervention and analysed using independent component analysis. RESULTS: Primary outcome: MBCT significantly reduced OCD symptoms compared to TAU (31.73% vs. 8.07% Y-BOCS reduction). SECONDARY OUTCOMES: the MBCT group also experienced reductions in depressive symptoms, rumination, perceived stress, and quality of life. No significant post-treatment changes were observed in resting-state connectivity. However, baseline connectivity demonstrated significant predictive value, with lower connectivity in preselected networks of interest, including the fronto-striatal, salience, and default mode networks, associated with greater reductions in Y-BOCS scores. CONCLUSION: MBCT is an effective strategy for individuals with moderately symptomatic OCD who continue to experience symptoms despite prior gold-standard treatments. While no post-treatment changes in brain functional connectivity were observed, baseline connectivity patterns predicted symptom reduction, suggesting a neural basis for MBCT response. .",
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            "source": "PubMed Central",
            "landing_page_url": "https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12707885\/",
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