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    "doi": "10.1152\/ajpregu.00164.2016",
    "status": "found",
    "title": "Sustained increases in blood pressure elicited by prolonged face cooling in humans",
    "authors": [
        "Zachary J. Schlader",
        "Gregory L. Coleman",
        "James R. Sackett",
        "Suman Sarker",
        "Blair D. Johnson"
    ],
    "container": "American Journal of Physiology-Regulatory, Integrative and Comparative Physiology",
    "year": "2016",
    "doi_url": "https:\/\/doi.org\/10.1152\/ajpregu.00164.2016",
    "is_open_access": false,
    "oa_status": "closed",
    "best_landing_page": "https:\/\/pubmed.ncbi.nlm.nih.gov\/27511278",
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    "abstract": "We tested the hypothesis that increases in blood pressure are sustained throughout 15 min of face cooling. Two independent trials were carried out. In the Face-Cooling Trial, 10 healthy adults underwent 15 min of face cooling where a 2.5-liter bag of ice water (0 ± 0°C) was placed over their cheeks, eyes, and forehead. The Sham Trial was identical except that the temperature of the water was 34 ± 1°C. Primary dependent variables were forehead temperature, mean arterial pressure, and forearm vascular resistance. The square root of the mean of successive differences in R-R interval (RMSSD) provided an index of cardiac parasympathetic activity. In the Face Cooling Trial, forehead temperature fell from 34.1 ± 0.9°C at baseline to 12.9 ± 3.3°C at the end of face cooling ( P < 0.01). Mean arterial pressure increased from 83 ± 9 mmHg at baseline to 106 ± 13 mmHg at the end of face cooling ( P < 0.01). RMSSD increased from 61 ± 40 ms at baseline to 165 ± 97 ms during the first 2 min of face cooling ( P ≤ 0.05), but returned to baseline levels thereafter (65 ± 49 ms, P ≥ 0.46). Forearm vascular resistance increased from 18.3 ± 4.4 mmHg·ml−1·100 g tissue−1·min at baseline to 26.6 ± 4.0 mmHg·ml−1·100 g tissue−1·min at the end of face cooling ( P < 0.01). There were no changes in the Sham Trial. These data indicate that increases in blood pressure are sustained throughout 15 min of face cooling, and face cooling elicits differential time-dependent parasympathetic and likely sympathetic activation.",
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            "source": "American Journal of Physiology-Regulatory, Integrative and Comparative Physiology",
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